SWS1

Names

[ Name ]:
SWS1

Biological Activity

[Description]:

SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[Target]

IC50: 1.8 nM (PD-1/PD-L1)[1]

[References]

[1]. Ding Z, et al. Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023 Aug 10;66(15):10364-10380..

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₅₃ClN₆O₅S

[ Molecular Weight ]:
849.48