H3B-968

Names

[ Name ]:
H3B-968

Biological Activity

[Description]:

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

Werner syndrome protein (WRN)[1]

[References]

[1]. Parker MJ, et al. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Biochemistry. 2023 Jul 18;62(14):2147-2160.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₈F₆N₄O₄S

[ Molecular Weight ]:
548.46

Related Compounds

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