Anti-inflammatory agent 41

Names

[ CAS No. ]:
2896204-90-1

[ Name ]:
Anti-inflammatory agent 41

Biological Activity

[Description]:

Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology

[In Vitro]

Anti-inflammatory agent 41 (13a) 显著减少了LPS诱导的p65在J774A.1巨噬细胞中的核转位。

[References]

[1]. Jun Yang, et al. Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis. Eur J Med Chem. 2023 Mar 5;249:115144.  

Chemical & Physical Properties

[ Molecular Formula ]:
C33H25N3O5

[ Molecular Weight ]:
543.57

Related Compounds

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