Isoxazole

Names

[ CAS No. ]:
288-14-2

[ Name ]:
Isoxazole

[Synonym ]:
EINECS 206-018-7
1-Oxa-2-azacyclopentadiene
Isoxazole
Isoxazoles
1,2-Oxazole
Isooxazole
MFCD00003149
Isoxazol
isoxazole acid

Biological Activity

[Description]:

Isoxazole is a drug scaffold that can be used to develop new drugs with various biological activities (e.g. anti-microbial, anti-viral, anti-cancer, anti-inflammatory, immunomodulatory, anti-convulsant or anti-diabetic properties)[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Zhu J, et al. The recent progress of isoxazole in medicinal chemistry. Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075.

[2]. Sysak A, et al. Isoxazole ring as a useful scaffold in a search for new therapeutic agents. Eur J Med Chem. 2017 Sep 8;137:292-309.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
95.5±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₃NO

[ Molecular Weight ]:
69.062

[ Flash Point ]:
8.9±0.0 °C

[ Exact Mass ]:
69.021461

[ PSA ]:
26.03000

[ LogP ]:
0.08

[ Vapour density ]:
2.4 (vs air)

[ Vapour Pressure ]:
51.7±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.422

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
F:Flammable;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S16-S23/33

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%