Ezatiostat (hydrochloride)

Names

[ Name ]:
Ezatiostat (hydrochloride)

[Synonym ]:
ethyl (2R)-[(4S)-4-amino-5-ethoxy-5-oxopentanoyl]-S-benzyl-L-cysteinyl-2- phenylglycinate hydrochloride
Ethyl (2S)-2-amino-5-{[(2R)-3-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate hydrochloride (1:1)
Ezatiostat hydrochloride
Ezatiostat HCl
TLK199
ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl] amino]-5-oxopentanoate hydrochloride
TER199
Glycine, L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, diethyl ester, monohydrochloride, (2R)-
Ezatiostat hydrochloride (USAN)
Telintra(R)
L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycinediethylestermonohydrochloride
Ezatiostat (hydrochloride)

Biological Activity

[Description]:

Ezatiostat hydrochloride is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase

Research Areas >> Cancer

[In Vitro]

Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

[References]

[1]. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20.

[Related Small Molecules]

ezatiostat | GSTO1-IN-1 | GSTO-IN-2

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₆ClN₃O₆S

[ Molecular Weight ]:
566.109

[ Exact Mass ]:
565.201355

[ PSA ]:
162.12000

[ LogP ]:
4.77990

[ Storage condition ]:
2-8℃

Related Compounds

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