ezatiostat

Names

[ Name ]:
ezatiostat

[Synonym ]:
Ethyl (2S)-2-amino-5-{[(2R)-3-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate
Ter-199
TLK-199
ezatiostat
UNII-057D10I8S8
Telintra
Terrapin 199

Biological Activity

[Description]:

Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase

Research Areas >> Cancer

[In Vitro]

Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

[References]

[1]. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20.

[Related Small Molecules]

GSTO1-IN-1 | Ezatiostat (hydrochloride) | GSTO-IN-2 | TLK117

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
749.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₃₅N₃O₆S

[ Molecular Weight ]:
529.648

[ Flash Point ]:
407.2±32.9 °C

[ Exact Mass ]:
529.224670

[ PSA ]:
169.10000

[ LogP ]:
4.27

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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