GSTO-IN-2

Names

[ CAS No. ]:
1202710-57-3

[ Name ]:
GSTO-IN-2

Biological Activity

[Description]:

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase

Research Areas >> Cancer

[Target]

IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)[1]

[In Vitro]

GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1].

[References]

[1]. Chang KH, et al. Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. Chem Commun (Camb). 2006 Feb 14;(6):629-31.

[Related Small Molecules]

ezatiostat | GSTO1-IN-1

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₅₂N₂O₉

[ Molecular Weight ]:
620.77

[ Storage condition ]:
2-8℃

Related Compounds

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