Firazorexton hydrate

Names

[ CAS No. ]:
2861934-86-1

[ Name ]:
Firazorexton hydrate

Biological Activity

[Description]:

Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). Firazorexton hydrate inhibits fragmentation of wakefulness and cataplexy-like episodes in mouse models of narcolepsy[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor)

Research Areas >> Neurological Disease

[Target]

EC50: 19 nM (OX2R)[1]

[References]

[1]. Ishikawa T, et al. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₅F₃N₂O₄S_.3/₂H₂O

[ Molecular Weight ]:
497.53

Related Compounds

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