Lerdelimumab

Names

[ Name ]:
Lerdelimumab

Biological Activity

[Description]:

Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad

Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad

Research Areas >> Neurological Disease

[In Vitro]

Lerdelimumab (10 μg/mL) 抑制 TGF-β2 诱导的所有作用，如：抑制 TGF-β2 刺激被膜袋转分化和收缩，诱导被膜袋的 MMP-2 和 -9 的释放[2]。

[In Vivo]

Lerdelimumab (100 μL，1 mg/mL；结膜下注射；在术后第 2、3、4、7、9、11 和 14 天) 明显改善青光眼手术结果，降低角膜副作用的风险[1]。

[References]

[1]. Mead AL, et al. Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3394-401.

[2]. Wormstone IM, et al. TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.