3-Nitrocoumarin

Names

[ CAS No. ]:
28448-04-6

[ Name ]:
3-Nitrocoumarin

[Synonym ]:
3-nitro-chromen-2-one
3-nitro-2H-chromen-2-one
3-nitrocoumarin
HMS545H12

Biological Activity

[Description]:

3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Research Areas >> Others

[Target]

PLC-γ[1].


[References]

[1]. Ward PD, et al. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. J Biol Chem. 2002 Sep 20;277(38):35760-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H5NO4

[ Molecular Weight ]:
191.14

[ Exact Mass ]:
191.02200

[ PSA ]:
76.03000

[ LogP ]:
2.22440

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Precursor & DownStream


Related Compounds