3-Nitrocoumarin

Names

[ CAS No. ]:
28448-04-6

[ Name ]:
3-Nitrocoumarin

[Synonym ]:
3-nitro-chromen-2-one
3-nitro-2H-chromen-2-one
3-nitrocoumarin
HMS545H12

Biological Activity

[Description]:

3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Others

[Target]

PLC-γ[1].

[References]

[1]. Ward PD, et al. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. J Biol Chem. 2002 Sep 20;277(38):35760-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₅NO₄

[ Molecular Weight ]:
191.14

[ Exact Mass ]:
191.02200

[ PSA ]:
76.03000

[ LogP ]:
2.22440

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.