TH470

Names

[ Name ]:
TH470

Biological Activity

[Description]:

TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)

Research Areas >> Neurological Disease

[Target]

LIMK1:9.8 nM (IC50)

LIMK2:13 nM (IC50)

[In Vitro]

TH470 (0.05-5 μM; 12 h) inhibits the growth of neurite[1]. Cell Viability Assay[1] Cell Line: N1E-115 cells transfected with siRNAs against FMR1 (siFMR1) or control siRNAs (siCtr) Concentration: 0.05, 0.5, or 5 μM Incubation Time: 12 hours Result: Inhibited neurite outgrowth in a dose-dependent manner.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₁N₅O₅S₂

[ Molecular Weight ]:
605.73

Related Compounds

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