FTX-6746

Names

[ CAS No. ]:
2829349-96-2

[ Name ]:
FTX-6746

Biological Activity

[Description]:

FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

[Target]

PPARγ

[In Vivo]

FTX-6746 (3-60 mg/kg；口服；每天 2 次，共 21 天) 在小鼠的 UMUC9 或 HT1197 异种移植模型中有显着的肿瘤抑制作用[1]。 Animal Model: UMUC9 or HT1197 xenograft model in NCG or Balb/C nude mice[1] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg, 60 mg/kg Administration: PO; twice daily for 21 days Result: Resulted >100% tumor growth inhibition at day 21 in HT1197 xenograft model. Resulted up to 80% target gene suppression in tumor tissue at day 2.

[References]

[1]. Mertz J, et al. Novel inhibitors of the luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) durably eradicate tumors in urothelial cancer (UC) animal models[J]. European Journal of Cancer, 2022, 174: S33-S34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₇ClF₂N₂O

[ Molecular Weight ]:
316.69

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.