Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer[1].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> Pim

IC50: 0.11 μM (Pim-1 kinase), 10.93 μM (MCF-7), 4.91 μM (CACO), 7.01 μM (HepG-2), 3.41 μM (HCT-116), 27.181 μM (WI-38)[1]

Pim-1 kinase inhibitor 1 (0-200 μM; 24 h) shows vitro cytotoxic activity to several cancer cells and affects cell apoptosis[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF-7, CACO, HepG-2, HCT-116 and WI-38 cells Concentration: 0-200 μM Incubation Time: 24 hours Result: Exhibited vitro cytotoxic activity to MCF-7, CACO, HepG-2, HCT-116 and WI-38 cell lines with IC50s of 10.93, 4.91, 7.01, 3.41 and 27.181 μM, respectively. Promoted apoptosis by increasing Casp-3, BAX and Bcl-2 concentration to achieve anti-cancer activity.

[1]. A. Ammar, et al. Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors. 2021.