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DABCO

Names

[ CAS No. ]:
280-57-9

[ Name ]:
DABCO

[Synonym ]:
T66 A B CN FNTJ
UNII-X8M57R0JS5
1,4-diazabicyclo-[2.2.2]octane
dabco33lv
1,4-Diazabicyclo[2.2.2]octane
1,4-diazabicyclo-[2.2.2]-octane
DABCO
TEDA-L33
diazabicyclooctane
1,4-diazabicyclo(2.2.2) octane
TED
BACO
1,4-diaza-bicyclo[2.2.2]octane
teda
triethylenediamine
Triethylene diamine
dabcoeg
EINECS 205-999-9
MFCD00006689
dabcos-25

Biological Activity

[Description]:

1,4-Diazabicyclo[2.2.2]octane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

1,4-二氮杂双环[2.2.2]辛烷用作聚氨酯催化剂,Balis-Hillman反应催化剂络合配体和路易斯碱。它可用于染料激光器和荧光显微镜的样品镶嵌,以及作为抗褪色剂显示可清除由于荧光染料激发荧光染料而产生的 Venge 自由基。此外,它还是一种氧化和聚合催化剂。

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
174.0±0.0 °C at 760 mmHg

[ Melting Point ]:
156-159 °C(lit.)

[ Molecular Formula ]:
C6H12N2

[ Molecular Weight ]:
112.17

[ Flash Point ]:
62.2±0.0 °C

[ Exact Mass ]:
112.100044

[ PSA ]:
6.48000

[ LogP ]:
-0.85

[ Vapour Pressure ]:
1.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.561

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but very hygroscopic. Incompatible with strong oxidizing agents, strong acids. Highly flammable.

[ Water Solubility ]:
46 g/100 mL (26 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HM0354200
CHEMICAL NAME :
1,4-Diazabicyclo(2,2,2)octane
CAS REGISTRY NUMBER :
280-57-9
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C6-H12-N2
MOLECULAR WEIGHT :
112.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,522,1962
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,522,1962 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4680 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0905 No. of Facilities: 334 (estimated) No. of Industries: 9 No. of Occupations: 15 No. of Employees: 1710 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0905 No. of Facilities: 1104 (estimated) No. of Industries: 23 No. of Occupations: 30 No. of Employees: 33913 (estimated) No. of Female Employees: 5787 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H412

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R22;R36/38;R41;R52/53

[ Safety Phrases ]:
S26-S60-S37/39-S3-S16-S36/37

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
HM0354200

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29335920

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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