N-Asn

Names

[ Name ]:
N-Asn

[Synonym ]:
2-Acetamido-1-N-(β-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine
2-Acetamido-2-deoxy-b-D-glucopyranosyl L-asparagine

Biological Activity

[Description]:

H-Asn(glcnac-beta-D)-OH is an endogenous metabolite present in Urine that can be used for the research of NGLY1-CDDG[1][2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372.

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Boiling Point ]:
818.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₂₁N₃O₈

[ Molecular Weight ]:
335.31000

[ Flash Point ]:
448.8ºC

[ Exact Mass ]:
335.13300

[ PSA ]:
191.44000

[ Vapour Pressure ]:
4.86E-31mmHg at 25°C

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues.

Carbohydr. Res. 331(4) , 439-44, (2001)

The syntheses of four analogues of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine are described. Activated carboxylic acids were reacted with 2-acetamido-2-deoxy-beta-D-glucopyranosylamin...

Aspartylglycosaminuria: biochemistry and molecular biology.

Biochim. Biophys. Acta 1455(2-3) , 139-54, (1999)

Aspartylglucosaminuria (AGU, McKusick 208400) is an autosomal recessive lysosomal storage disease caused by defective degradation of Asn-linked glycoproteins. AGU mutations occur in the gene (AGA) for...

Angiokeratoma corporis diffusum in a Spanish patient with aspartylglucosaminuria.

Br. J. Dermatol. 147(4) , 760-4, (2002)

Angiokeratoma corporis diffusum (ACD), initially considered to be synonymous with Fabry's disease, represents a well-known cutaneous marker of some other lysosomal enzyme disorders. Aspartylglucosamin...