DB1113

Names

[ Name ]:
DB1113

Biological Activity

[Description]:

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAP4K

Signaling Pathways >> MAPK/ERK Pathway >> MAPKAPK2 (MK2)

Research Areas >> Others

Signaling Pathways >> Apoptosis >> Ferroptosis

Signaling Pathways >> Autophagy >> ULK

Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)

[Target]

CDK4

CDK11B

MAP4K2

SIK2

SIK3

MAP4K5

HPK1

GLK/MAP4K3

ULK1

LIMK1

[References]

[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₉H₆₈F₃N₁₃O₆S

[ Molecular Weight ]:
1144.31