RSS0680

Names

[ Name ]:
RSS0680

Biological Activity

[Description]:

RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Wee1

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)

[Target]

CDK1

CDK2

CDK4

CDK6

SIK2

CDK16/Cyclin Y

[References]

[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₂H₆₄N₁₀O₆S₃

[ Molecular Weight ]:
1021.32

Related Compounds

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