Tropatepine

Names

[ Name ]:
Tropatepine

[Synonym ]:
(1R,5S)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]tropane
3-(6H-dibenzo[b,e]thiepin-11-ylidene)-8-methyl-nortropane

Biological Activity

[Description]:

Tropatepine is an anticholinergic muscarinic antagonist and can be used as an antiparkinsonian agent[1]. Tropatepine is used to combat against extrapyramidal syndrome induced by neuroleptic drugs[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. P Celsis, et al. Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):917-8.

[2]. P Arnoux, et al. Simultaneous determination of tropatepine and its major metabolites by high-performance liquid chromatographic-mass spectrometric identification. Application to metabolic and kinetic studies. J Chromatogr. 1986 Aug 22;381(1):75-82.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
493.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₃NS

[ Molecular Weight ]:
333.49000

[ Flash Point ]:
252ºC

[ Exact Mass ]:
333.15500

[ PSA ]:
28.54000

[ LogP ]:
5.28870

[ Vapour Pressure ]:
7.23E-10mmHg at 25°C

[ Index of Refraction ]:
1.654

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL5608700

CHEMICAL NAME :: 8-Azabicyclo(3.2.1)octane, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-8-methyl-

CAS REGISTRY NUMBER :: 27574-24-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H23-N-S

MOLECULAR WEIGHT :: 333.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3725415

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%