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Leucettinib-92

Names

[ CAS No. ]:
2732859-57-1

[ Name ]:
Leucettinib-92

Biological Activity

[Description]:

Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC50s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3)[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Research Areas >> Others
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

IC50: 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3)[1]


[References]

[1]. Deau E, et al. Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B. J Med Chem. 2023 Aug 10;66(15):10694-10714.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H22N4OS

[ Molecular Weight ]:
378.49

Related Compounds