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EGFR-IN-30

Names

[ CAS No. ]:
2726463-68-7

[ Name ]:
EGFR-IN-30

Biological Activity

[Description]:

EGFR-IN-30 is a potent EGFR inhibitor with IC50s of 1-10 nM, <1 nM for EGFR (WT), EGFR (L858R/T790M/C797S), respectively. EGFR-IN-30 has potential for cell proliferative diseases, such as cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR (WT):1-10 nM (IC50)

EGFR (L858R/T790M/C797S):<1 nM (IC50)


[In Vitro]

EGFR-IN-30 (compound 27) inhibits A431 cell (IC50=100-1000 nM),Ba/F3_L858R/T790M/C797S cell (IC50<10 nM), Ba/F3_Del19/T790M/C797S cell (IC50<10 nM)[1].

[References]

[1]. Shansong Zheng, et al. Tricyclic compounds as EGFR inhibitors. WO2021208918A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H33BrN7O2P

[ Molecular Weight ]:
610.49

Related Compounds