4-Butyl-alpha-agarofuran

4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research[1].

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

在人肝微粒体培养体系中，4-Butyl-alpha-agarofuran (2 mg) 在 100 分钟内完全代谢为羟基衍生物 I 和羰基衍生物 II[2]。

4-Butyl-alpha-agarofuran (0.5-10 mg/kg；腹腔注射，1 次) 在社交互动测试中显示出抗焦虑作用，显著降低纹状体、皮层和中脑的血清素 (5-HT) 水平[1]。 Animal Model: Male Wistar rats[1] Dosage: 0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg Administration: Intraperitoneal injection; 0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg; once Result: Dose-dependently prolonged the total time spent in social interaction test at a dose range of 0.5-2.0 mg/kg. Decreased the 5-HT levels in brain tissues, decreased dopamine levels of in rat striatum and midbrain and also reduced the cortical level of epinephrine at a dose of 5 mg/kg after acute administration. Decresed the extracellular dopamine level in the striatum at a dose of 10 mg/kg.

[1]. Zhang Y, et al. Effects of novel anxiolytic 4-butyl-alpha-agarofuran on levels of monoamine neurotransmitters in rats. Eur J Pharmacol. 2004 Nov 3;504(1-2):39-44.  

[2]. Li N, et al. [In vitro metabolic studies of the novel anti-anxietic drug AF-5 and its metabolites in human liver microsome incubation system]. Yao Xue Xue Bao. 2001 Jul;36(7):528-31. Chinese.