Miltirone

Names

[ Name ]:
Miltirone

[Synonym ]:
3,4-Phenanthrenedione, 5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-
Miltiron
2-Isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-3,4-phenanthrenedione
Miltirone
Rosmariquinone
2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-phenanthrene-3,4-dione

Biological Activity

[Description]:

Miltirone is a natural compound present in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. C M Lee, et al. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett. 1991 Jun 24;127(2):237-41.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
421.6±45.0 °C at 760 mmHg

[ Melting Point ]:
98-100℃ (hexane )

[ Molecular Formula ]:
C₁₉H₂₂O₂

[ Molecular Weight ]:
282.377

[ Flash Point ]:
179.4±14.4 °C

[ Exact Mass ]:
282.161987

[ PSA ]:
34.14000

[ LogP ]:
5.67

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.556

Safety Information

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%