MMK1

Names

[ Name ]:
MMK1

Biological Activity

[Description]:

MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK-1 potently activated phagocytic leukocytes and could enhance Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

Calcium Channel

[In Vitro]

MMK-1 induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with a 50% effective concentration (EC50) at 2 nM[1]. MMK1 (1 μM; for 4 h) induces selective migration of FPR2-expressing RBL-2H3 cells[3].

[In Vivo]

MMK1 (10-1000 pmol; ICV; 20 min before the test) exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse[4]. Animal Model: Four-week-old male ddY mice[4] Dosage: 10, 100, 1000 pmol/mouse Administration: ICV; 20 min before the test Result: Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.

[References]

[1]. C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7.

[2]. Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975.

[3]. Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664.

[4]. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₅H₁₂₃N₁₉O₁₈S

[ Molecular Weight ]:
1610.96000

[ Exact Mass ]:
1609.90000

[ PSA ]:
639.38000

[ LogP ]:
5.44370

Related Compounds

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