G2019S-LRRK2 inhibitor 38
Names
[ CAS No. ]:
2704564-03-2
[ Name ]:
G2019S-LRRK2 inhibitor 38
Biological Activity
[Description]:
G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice.
[References]
1. Robert K Leśniak, et al. Eur J Med Chem. 2022 Feb 5;229:114080.
Chemical & Physical Properties
[ Molecular Formula ]:
C24H21N5
[ Molecular Weight ]:
379.467
Related Compounds
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