LRRK2-IN-10

Names

[ CAS No. ]:
2704562-80-9

[ Name ]:
LRRK2-IN-10

Biological Activity

[Description]:

LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2
Research Areas >> Neurological Disease

[References]

[1]. Albert W Garofalo, et al. Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H15N5O

[ Molecular Weight ]:
341.37

Related Compounds

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