2704562-80-9

2704562-80-9 structure

Name: LRRK2-IN-10
Chemical Name: LRRK2-IN-10
CAS Number: 2704562-80-9
Molecular Formula: C₂₀H₁₅N₅O
Molecular Weight: 341.37
Catalog: Signaling Pathways Autophagy LRRK2
Create Date: 2023-12-22 12:14:54
Modify Date: 2024-02-05 19:37:28
LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research[1].

Name	LRRK2-IN-10

Description	LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research[1].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
References	[1]. Albert W Garofalo, et al. Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.

Molecular Formula	C₂₀H₁₅N₅O
Molecular Weight	341.37