O-Benzylhydroxylamine hydrochloride

Names

[ Name ]:
O-Benzylhydroxylamine hydrochloride

[Synonym ]:
phenylmethoxyamine hydrochloride
Benzylhydroxylamine HCl
[(aminooxy)methyl]benzolhydrochlorid
[(Aminooxy)methyl]benzene hydrochloride
2-BenzylhydroxylamineHcl
O-benzylhydroxylamine hydrochloride
MFCD00012952
O-BENZYLHYDROXYLAMINE HCL
[(Aminooxy)methyl]benzene hydrochloride (1:1)
BENZYLOXYAMINE
Benzyloxyammonium Chloride
O-benzylhydroxylammonium chloride
EINECS 220-249-0
BENZYLOXYAMINE HCL
Hydroxylamine, O- (phenylmethyl)-, hydrochloride
Benzene, [(aminooxy)methyl]-, hydrochloride (1:1)

Biological Activity

[Description]:

O-Benzylhydroxylamine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

O-Benzylhydroxylamine 是一种基本成分。它已被用于合成 β-内酰胺抑制剂前体和具有抗生素活性的氟喹诺酮类衍生物。

[References]

[1]. Bellettini, JR, and Miller, MJA short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997)

[2]. Asadipour, A., Moshafi, MH, Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)199-207(2018)

Chemical & Physical Properties

[ Boiling Point ]:
237.5ºC at 760 mmHg

[ Melting Point ]:
238 °C (subl.)(lit.)

[ Molecular Formula ]:
C₇H₁₀ClNO

[ Molecular Weight ]:
159.61

[ Flash Point ]:
113.1ºC

[ Exact Mass ]:
159.045090

[ PSA ]:
35.25000

[ LogP ]:
2.57920

[ Vapour Pressure ]:
0.00923mmHg at 25°C

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NC3040000

CHEMICAL NAME :: Hydroxylamine, O-benzyl-, hydrochloride

CAS REGISTRY NUMBER :: 2687-43-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-N-O.Cl-H

MOLECULAR WEIGHT :: 159.63

WISWESSER LINE NOTATION :: ZO1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S8

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NC3040000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Determination of carbohydrates in tobacco by pressurized liquid extraction combined with a novel ultrasound-assisted dispersive liquid-liquid microextraction method.

Anal. Chim. Acta 882 , 90-100, (2015)

A novel derivatization-ultrasonic assisted-dispersive liquid-liquid microextraction (UA-DLLME) method for the simultaneous determination of 11 main carbohydrates in tobacco has been developed. The com...

Capillary gas-chromatographic analysis of monosaccharides: improvements and comparisons using trifluoroacetylation and trimethylsilylation of sugar O-benzyl- and O-methyl-oximes.

Carbohydr. Res. 194 , 1, (1989)

Two new procedures for the gas-chromatographic analysis of monosaccharides are reported. One involves derivatization of the sugars by reaction with O-benzylhydroxylamine followed by trifluoroacetylati...

Thermodynamic analysis of the binding of aromatic hydroxamic acid analogues to ferric horseradish peroxidase.

Biochemistry 40(46) , 13980-9, (2001)

Peroxidases typically bind their reducing substrates weakly, with K(d) values in the millimolar range. The binding of benzhydroxamic acid (BHA) to ferric horseradish peroxidase isoenzyme C (HRPC) [K(d...