PPARγ-IN-2

Names

[ CAS No. ]:
2682078-97-1

[ Name ]:
PPARγ-IN-2

Biological Activity

[Description]:

PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Metabolic Disease

[Target]

PPARγ


[References]

[1]. Guo SY, et al. Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism. Eur J Med Chem. 2023 Nov 15;260:115729.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H21N5O

[ Molecular Weight ]:
335.40

Related Compounds