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BML-259

Names

[ CAS No. ]:
267654-00-2

[ Name ]:
BML-259

[Synonym ]:
2-phenyl-N-[5-(propan-2-yl)-1,3-thiazol-2-yl]acetamide
Benzeneacetamide, N-[5-(1-methylethyl)-2-thiazolyl]-
N-(5-Isopropyl-1,3-thiazol-2-yl)-2-phenylacetamide

Biological Activity

[Description]:

BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Research Areas >> Neurological Disease

[In Vitro]

BML-259 (10 μM) protects large population of cells against non-Aβ component of Alzheimer's disease amyloid (NAC)-evoked cell death[2].

[References]

[1]. Kaźmierczak A, et al. A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5). Neurochem Int. 2011;58(2):206-214.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C14H16N2OS

[ Molecular Weight ]:
260.35

[ Exact Mass ]:
260.098328

[ PSA ]:
70.23000

[ LogP ]:
3.88

[ Index of Refraction ]:
1.618

Related Compounds