JPS036

Names

[ Name ]:
JPS036

Biological Activity

[Description]:

JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₆₆FN₇O₇S

[ Molecular Weight ]:
940.18

Related Compounds

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