2669785-85-5

2669785-85-5 structure

Name: JPS036
Chemical Name: JPS036
CAS Number: 2669785-85-5
Molecular Formula: C₅₁H₆₆FN₇O₇S
Molecular Weight: 940.18
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-07-28 19:34:53
Modify Date: 2024-01-14 10:44:58
JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Name	JPS036

Description	JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

Molecular Formula	C₅₁H₆₆FN₇O₇S
Molecular Weight	940.18