ZDWX-25

Names

[ CAS No. ]:
2668297-70-7

[ Name ]:
ZDWX-25

Biological Activity

[Description]:

ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Neurological Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3β:71 nM (IC50)


[References]

[1]. Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H15N3O3

[ Molecular Weight ]:
309.32

Related Compounds

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