CypD-IN-3

Names

[ CAS No. ]:
2651994-75-9

[ Name ]:
CypD-IN-3

Biological Activity

[Description]:

CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

IC50: 0.01 μM (CypD); 1.1 μM (CypA); 0.21 μM (CypB); 0.31μM (CypE)[1]

[In Vitro]

CypD-IN-3 (B52) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC50 values of 0.01 μM, 1.1 μM, 0.21 μM and 0.31 μM, respectively[1]. CypD-IN-3 (10 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₆₁N₇O₁₁

[ Molecular Weight ]:
972.09

Related Compounds

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