ARN25068

Names

[ Name ]:
ARN25068

Biological Activity

[Description]:

ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

Research Areas >> Neurological Disease

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[In Vitro]

ARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively[1].

[References]

[1]. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₈N₆S

[ Molecular Weight ]:
362.45

Related Compounds

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