CDK5-IN-2

Names

[ Name ]:
CDK5-IN-2

Biological Activity

[Description]:

CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

Cdk5/p25:0.2 nM (IC50)

CDK2/CycA:23 nM (IC50)

[References]

[1]. Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₈FN₅O

[ Molecular Weight ]:
481.56

Related Compounds

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