DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

Names

[ CAS No. ]:
263718-22-5

[ Name ]:
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

[Synonym ]:
MALARIA ASPARTYL PROTEINASE SUBSTRATE
MALARIA ASPARTYL PROTEINASE FRET SUBSTRATE I
DABCYL-GLU-ARG-NLE-PHE-LEU-SER-PHE-PRO-EDANS
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

Biological Activity

[Description]:

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS (10 μM) can be used in the plasmepsin assay to mimic the cleavage site present in hemoglobin (kcat: 0.78 /s, Km: 0.10 μM, for P. falciparum plasmepsin; and kcat: 0.69 /s, Km: 0.16 μM, for P. vivaxplasmepsin.

[References]

[1]. S Jiang, et al. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins. Antimicrob Agents Chemother. 2001 Sep;45(9):2577-84.

Chemical & Physical Properties

[ Molecular Formula ]:
C76H98N16O15S

[ Molecular Weight ]:
1507.75000

[ Exact Mass ]:
1506.71000

[ PSA ]:
475.28000

[ LogP ]:
10.04630

MSDS

Click to get detail MSDS

Related Compounds

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