263718-22-5

263718-22-5 structure

Name: DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt
Chemical Name: Malaria Aspartyl Proteinase FRET Substrate I,[DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS]
CAS Number: 263718-22-5
Molecular Formula: C₇₆H₉₈N₁₆O₁₅S
Molecular Weight: 1507.75000
Catalog: Research Areas Others
Create Date: 2018-12-04 09:10:00
Modify Date: 2024-01-09 18:39:29
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].

Name	Malaria Aspartyl Proteinase FRET Substrate I,[DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS]
Synonyms	MALARIA ASPARTYL PROTEINASE SUBSTRATE MALARIA ASPARTYL PROTEINASE FRET SUBSTRATE I DABCYL-GLU-ARG-NLE-PHE-LEU-SER-PHE-PRO-EDANS DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

Description	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS (10 μM) can be used in the plasmepsin assay to mimic the cleavage site present in hemoglobin (kcat: 0.78 /s, Km: 0.10 μM, for P. falciparum plasmepsin; and kcat: 0.69 /s, Km: 0.16 μM, for P. vivaxplasmepsin.
References	[1]. S Jiang, et al. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins. Antimicrob Agents Chemother. 2001 Sep;45(9):2577-84.