PTP inhibitor 1

Names

[ Name ]:
PTP inhibitor 1

[Synonym ]:
α-Bromo-4'-methoxyacetophenone
p-methoxyphenacyl bromide
4'-Methoxyphenacyl Bromide
4-Methoxyphenacyl Br
ω-Bromo-4-methoxyacetophenone
2-Bromo-1-(4-methoxyphenyl)ethanone
4-Methoxyphenacyl bromide
2-Bromo-4′-methoxyacetophenone
2-Bromo-4‘-methoxyacetophenone
Acetophenone, 2-bromo-4'-methoxy-
2-Bromo-4'-methoxyacetophenone
MFCD00465443
2-bromo-1-(4'-methoxy-phenyl)-ethanone
2-Bromo-4'-methoxyacetophenone, Pract.
Ethanone,2-bromo-1-(4-methoxyphenyl)
1-(4-methoxyphenyl)-2-bromo-ethan-1-one
Ethanone, 2-bromo-1-(4-methoxyphenyl)-
EINECS 220-118-8
4-(Bromoacetyl)anisole

Biological Activity

[Description]:

PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

PTP[1]

[In Vitro]

PTP inhibitor 1 exhibits anti-angiogenic activity with an IC50 of 3.7 μM for HUVECs[1].

[References]

[1]. Sylvest L, et al. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS. 2010 Jan;118(1):49-59.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
306.7±17.0 °C at 760 mmHg

[ Melting Point ]:
69-71 °C(lit.)

[ Molecular Formula ]:
C₉H₉BrO₂

[ Molecular Weight ]:
229.071

[ Flash Point ]:
139.3±20.9 °C

[ Exact Mass ]:
227.978592

[ PSA ]:
26.30000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45-S37/39

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29147090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

J. Med. Chem. 54 , 4042-56, (2011)

Development of kinase-targeted therapies for central nervous system (CNS) diseases is a great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe CNS unmet diseases, bein...

QSAR study and conformational analysis of 4-arylthiazolylhydrazones derived from 1-indanones with anti-Trypanosoma cruzi activity.

Eur. J. Pharm. Sci. 78 , 190-7, (2015)

A set of 4-arylthiazolylhydrazones derived from 1-indanones (TZHs) previously synthesized and assayed against Trypanosoma cruzi, the causative agent of Chagas disease, were explored in terms of confor...

Synthesis of diblock copolymers bearing p-methoxyphenacyl side groups.

Polym. Chem. 2(10) , 2284-2292, (2011)

Related Compounds

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