Efflux inhibitor-1

Names

[ CAS No. ]:
1776055-29-8

[ Name ]:
Efflux inhibitor-1

Biological Activity

[Description]:

Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC50s of 0.45 μM and 2.17 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP

[Target]

IC50: 0.45 μM (ABCG2/BCRP), 2.17 μM (ABCB1)[1]


[References]

[1]. Larson, et al. Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment: United States, US9056111[P]. 2015-06-16.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H25N5O3

[ Molecular Weight ]:
479.53

Related Compounds