Adenosine,2'-chloro-2'-deoxy-

Names

[ Name ]:
Adenosine,2'-chloro-2'-deoxy-

[Synonym ]:
2'-deoxy-2'-chloroadenosine
2'-Chlor-2'-deoxy-adenosin
Adenosine,2'-chloro-2'-deoxy
2'-chloro-2'-deoxy-adenosine

Biological Activity

[Description]:

2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.03g/cm3

[ Boiling Point ]:
678.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂ClN₅O₃

[ Molecular Weight ]:
285.69

[ Flash Point ]:
364ºC

[ Exact Mass ]:
285.06300

[ PSA ]:
119.31000

[ Vapour Pressure ]:
2.54E-19mmHg at 25°C

[ Index of Refraction ]:
1.87

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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