Artemisiane E

Names

[ CAS No. ]:
2618700-77-7

[ Name ]:
Artemisiane E

Biological Activity

[Description]:

Artemisiane E (Compound 8) is a potent PI3K/AKT pathway inhibitor with an IC50 of 8.9 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

IC50: 8.9 μM (PI3K/AKT pathway)[1]

[In Vitro]

Artemisiane E (Compound 8) (25 and 50 μM) inhibits AKT activity in MM121224 cells[1].

[References]

[1]. Dürr L, et al. A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signaling in Melanoma Cells. J Nat Prod. 2022 Nov 25;85(11):2557-2569.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂O₅

[ Molecular Weight ]:
342.39

Related Compounds

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