Funalenone

Names

[ Name ]:
Funalenone

[Synonym ]:
8-deoxyxanthoherquein
Funalenone
1H-Phenalen-1-one,3,4,7,9-tetrahydroxy-2-methoxy-6-methyl
3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one

Biological Activity

[Description]:

Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

collagenases 1

HIV Integrase:10 μM (IC50)

[References]

[1]. J Inokoshi, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100.

[2]. Zawadzke LE, et al. Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention. Anal Biochem. 2003 Mar 15;314(2):243-52.

[3]. Kazuro Shiomi, et al. Fungal phenalenones inhibit HIV-1 integrase. J Antibiot (Tokyo). 2005 Jan;58(1):65-8.

[4]. Inokoshi J, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₂O₆

[ Molecular Weight ]:
288.25

[ Exact Mass ]:
288.06300

[ PSA ]:
107.22000

[ LogP ]:
2.27040

Related Compounds

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