Azido-PEG2-VHL

Names

[ CAS No. ]:
2597167-22-9

[ Name ]:
Azido-PEG2-VHL

Biological Activity

[Description]:

Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. STATSYUK A, et, al. Multikinase degraders. WO2021021797A1.

[2]. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₁N₇O₆S

[ Molecular Weight ]:
615.74

Related Compounds

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