PXS-6302 hydrochloride

Names

[ Name ]:
PXS-6302 hydrochloride

Biological Activity

[Description]:

PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Inflammation/Immunology

[References]

[1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₁ClF₃NO₂S

[ Molecular Weight ]:
301.71