KTX-955

Names

[ CAS No. ]:
2573302-50-6

[ Name ]:
KTX-955

Biological Activity

[Description]:

KTX-955 is a potent IRAK4 degrader with DC50 values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively. KTX-955 can be used to research anticancer[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4:5 nM (IC50)


[In Vitro]

KTX-955 (compound I-312) degrades IRAK4 in OCI-LY10 at 24 hours with an IC50 of <0.05 μM[1].

[References]

[1]. Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS).

[2]. Nello Mainolfi, et al. Irak degraders and uses thereof. WO2020264499A1

Chemical & Physical Properties

[ Molecular Formula ]:
C46H51F3N8O7

[ Molecular Weight ]:
884.94

Related Compounds