KTX-612

Names

[ CAS No. ]:
2573298-14-1

[ Name ]:
KTX-612

Biological Activity

[Description]:

KTX-612 is an orally active IRAK4 degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4:7 nM (DC50)


[In Vitro]

KTX-612 has activity for IRAK4 with a DC50 value of 7 nM[1].

[In Vivo]

KTX-612 (oral; 10 mg/kg) impacts oral absorption[1]. Animal Model: Rat[1] Dosage: 10 mg/kg Administration: Oral Result: Rat PO PK (10 mg/kg) KTX-612 %F 1 AUC(μM*hr) 0.060

[References]

[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Chemical & Physical Properties

[ Molecular Formula ]:
C46H51F3N8O6

[ Molecular Weight ]:
868.94

Related Compounds