KSK67

Names

[ Name ]:
KSK67

Biological Activity

[Description]:

KSK67 is a high-affinity dual sigma-2 and histamine H3 receptor antagonist, with Kis of 3.2, 1531, 101 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK67 can be used for research of nociceptive and neuropathic pain[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

3.2, 1531, 101 nM (H3 receptor, sigma-1, sigma-2 receptor)[1]

[References]

[1]. Szczepańska K, et al. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 27;66(14):9658-9683.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₇N₃O₂

[ Molecular Weight ]:
365.47

Related Compounds

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