COX-2-IN-21

Names

[ CAS No. ]:
2519631-11-7

[ Name ]:
COX-2-IN-21

Biological Activity

[Description]:

COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2:0.039 μM (IC50)

COX-1:12.4 μM (IC50)

[In Vitro]

COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib[1]. COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE2 greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib[1].

[References]

[1]. Labib MB, et al. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study. Bioorg Chem. 2020 Nov;104:104308.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂N₆O₄

[ Molecular Weight ]:
422.44

Related Compounds

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