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2519631-11-7

2519631-11-7 structure

2519631-11-7 structure

Name: COX-2-IN-21
Chemical Name: COX-2-IN-21
CAS Number: 2519631-11-7
Molecular Formula: C₂₁H₂₂N₆O₄
Molecular Weight: 422.44
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-08-12 12:02:15
Modify Date: 2025-08-26 17:15:06
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].

Name	COX-2-IN-21

Description	COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.039 μM (IC50) COX-1:12.4 μM (IC50)
In Vitro	COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib[1]. COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE2 greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib[1].
References	[1]. Labib MB, et al. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study. Bioorg Chem. 2020 Nov;104:104308.

Molecular Formula	C₂₁H₂₂N₆O₄
Molecular Weight	422.44

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