Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2519631-11-7

2519631-11-7 structure

2519631-11-7 structure

Name: COX-2-IN-21
Chemical Name: COX-2-IN-21
CAS Number: 2519631-11-7
Molecular Formula: C₂₁H₂₂N₆O₄
Molecular Weight: 422.44
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-08-12 12:02:15
Modify Date: 2024-09-17 12:47:24
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].

Name	COX-2-IN-21

Description	COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.039 μM (IC50) COX-1:12.4 μM (IC50)
In Vitro	COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib[1]. COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE2 greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib[1].
References	[1]. Labib MB, et al. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study. Bioorg Chem. 2020 Nov;104:104308.

Molecular Formula	C₂₁H₂₂N₆O₄
Molecular Weight	422.44

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.