<Suppliers Price>

DHODH-IN-16

Names

[ CAS No. ]:
2511248-11-4

[ Name ]:
DHODH-IN-16

Biological Activity

[Description]:

DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: 0.396 nM (human DHODH)[1]


[In Vitro]

DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM[1].

[References]

[1]. Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25FN4O3

[ Molecular Weight ]:
436.48

Related Compounds